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הידעת? הדפדפן שהינך גולש ממנו אינו עדכני

הדפדפן שהינך גולש ממנו אינו עדכני ויתכן שהאתר אינו יעבוד בצורה טובה. הדפדפנים הנתמכים באתר הם:

לחץ על האיקונים למעבר לדף ההורדה של הדפדפן

סגירת חלונית אל תציג בשנית

בסגירת החלונית תועבר/י לאתר מותאם לדפדפן ויתכן כי חלק מהאתר לא יעבוד בצורה מיטבית

Authority for R & D diabetes research laboratory

diabetes research laboratory

הדפסה דוא

Members

Dr. Rosenzweig, Tovit

General Research Interests

Diabetes (mainly type 2) is a common metabolic disease, characterized by an absolute or relative reduction in plasma insulin concentration. Taking into account the severe complications of the disease, diabetes is recognized to be pandemic, with major public health concerns. Therefore, prevention of diabetes and delay of the progression of prediabetes is of high priority.

In our lab we investigate the efficiency of several nutritional and herbal supplements for the prevention and treatment of diabetes. The physiological and molecular mechanisms of action are both investigated.

Our current research focuses on the following topics:

Antioxidants for the prevention of diabetes:

Oxidative stress is a common denominator in many diseases, including diabetes. As a result of promising results obtained from in-vitro and in-vivo studies showing the beneficial function of antioxidants in the prevention of diseases, including benefits of antioxidants on insulin sensitivity and β-cell viability and function, supplementation of antioxidants became very popular. Unfortunately, major randomized clinical trials have yielded disappointing results. Meta analyses conclude that antioxidant supplementations have no beneficial effects on the prevalence of type 2 diabetes.

Our hypothesis is that there is an optimal redox state that should normally be maintained in cells. If shifted either to the oxidized or to the reduced state, disturbances in β-cell function and in insulin sensitivity of target tissues appear. In our study we investigate the effect of antioxidants on the prevention of diabetes, and clarify the correlation between redox potential and the development of diabetes.

Research and development of herbal drug, based on Sarcopoterium spinosum, for the treatment of diabetes

Sarcopoterium spinosum (Sira kotzanit, Thorny burnet) is an abundant plant in Israel, used by Beduin medicinal practitioners for the treatment of diabetes. In our study we validated the anti-diabetic activity of S.spinosum and clarify its mechanism of action.

Function of adipose tissue in relation to diabetes

The role of adipose tissue in regulating diverse physiological functions in health and disease has been investigated in depth in the last 2 decades. By secreting wide range of adipokines, adipose tissue affects a wide range of physiological functions.  Among the enormous battery of adipokines, adiponectin is uniquely known as an important and beneficial factor, which is positively correlated with insulin sensitivity, and negatively correlated with metabolic syndrome risk and systemic inflammation. In our lab we clarify the autocrine effects of adiponectin on adipocytes differentiation and function.

עדכון אחרון ב-שלישי, 15 אוקטובר 2013 16:55
 

 

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