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הידעת? הדפדפן שהינך גולש ממנו אינו עדכני

הדפדפן שהינך גולש ממנו אינו עדכני ויתכן שהאתר אינו יעבוד בצורה טובה. הדפדפנים הנתמכים באתר הם:

לחץ על האיקונים למעבר לדף ההורדה של הדפדפן

סגירת חלונית אל תציג בשנית

בסגירת החלונית תועבר/י לאתר מותאם לדפדפן ויתכן כי חלק מהאתר לא יעבוד בצורה מיטבית

Authority for R & D Stem cells and Neurodegenerative Diseases

Physical Training, Neuroimmunology and Neuroregeneration

הדפסה דוא

Head of the Laboratory

Ofira Einstein, BPT, PhD

 

Main Research Areas

  • Physical Training and the Central Nervous System
  • Physical Training and Neuroimmunology
  • Physical Training and Neuroregeneration
  • Effects of Physical Training on Experimental Autoimmune Encephalomyelitis (EAE), the animal model of Multiple Sclerosis (MS)

 

Exercise training inhibits the encephalitogenicity of lymph node (LN) T cell- derived from proteolipid (PLP) - immuunized mice, but does not induce CNS protective mechanisms in transfer model of experimental autoimmune encephalomyelitis (EAE). 

Figure 2

 Clinical course (A) and clinical parameters (B) of transfer EAE in mice that received PLP-reactive LN T cells from trained mice (trained- transfer EAE) or from sedentary mice (sedentary- transfer EAE). Clinical course (C) and clinical parameters (D) of transfer EAE in trained mice (trained EAE) and sedentary mice (sedentary EAE). Transfer of LN T cells derived from trained, PLP-immunized mice to naïve recipients induced a significantly milder EAE course (A, B). Exercise training did not affect the clinical course of EAE in trained mice that were injected with encephalitogenic PLP- reactive LN- T cells (C, D). The severity of EAE was scored according to a 0–6 scale. MCS – maximal clinical score; BOD – burden of disease (area under curve). Data are represented as mean ± SE. *p<0.05.

Taken from Einstein O. et al., Exp. Neurol., 2017

 

 

Attenuation of pathological parameters of experimental autoimmune encephalomyelitis (EAE) mice injected with proteolipid (PLP)- reactive LN- T cells from trained mice. 

Figures 3 rev

Pathological evaluation of axonal damage (A-F) and demyelination (G-I) was performed in the spinal cords of EAE mice that were injected with LN- T cells from control sedentary mice (A, D, G; n=6) or with LN- T cells from trained mice (B, E, H; n=6) . C, F, I – measurements of tissue pathology in spinal cord white matter of sedentary- transfer EAE (Sed-tr EAE) mice and trained- transfer EAE (Trained-tr EAE) mice. In Trained-tr EAE there were less amyloid precursor protein (APP)+ injured axons (B, arrows) than in Sed-tr EAE (A, arrows; C). Bielschowsky staining showed less axonal damage and axonal loss in Trained-tr EAE mice (E) than in control Sed-tr EAEmice (D, F). Luxol fast blue staining showed reduction in the area of demyelination in Trained-tr EAE (H) vs. Sed-tr EAE EAE mice (G, I). Data are represented as mean ± SE. *p

Taken from Einstein O. et al., Exp. Neurol., 2017

 

עדכון אחרון ב-רביעי, 25 אוקטובר 2017 00:19
 

 

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