Research topics

Klebsiella pneumoniae multidrug resistance

K. pneumoniae, light microscopy


C. elegans is used as an animal model to study Klebsiella pathogenesis in vivo

Multidrug-resistant virulent Klebsiella pneumoniae

Global bacterial multidrug resistance is a major worldwide issue. This is especially crucial for life-threatening bloodstream infections associated with bad outcome.
Klebsiella pneumoniae is a dangerous multi-resistant pathogen that causes severe bloodstream infections. We decipher the molecular mechanisms involved in serum resistance of this pathogen that may aid in the development of a novel targeted anti-Klebsiella drug.
50% of all K. pneumoniae isolates are MDR due to carriage of extended-spectrum-β-lactamase-(ESBL)-encoding plasmids. We study the impact of a representative set of ESBL-encoding plasmid on K. pneumoniae virulence and pathogenesis using a multiple molecular and translational approaches. Dorit Cohen-Eli, PhDAyala Gancz

Escherichia coli genetic content

Genetic content of E. coli

Escherichia coli ST131 isolate 461 plasmid p461 map

Map of ST131 plasmid p461.
This plasmid harbors ten antibiotic resistance genes and confers resistance to three classes of antibiotics. A complete conjugation region may be used for the plasmid sharing

Multidrug resistance encoding plasmids

Plasmids are extrachromosomal DNA molecules which usually encode additional genetic traits. We investigate plasmids providing multidrug resistance (MDR) to very widespread pathogen E. coli sequence type (ST) 131. Diversity and evolution of the plasmids are under the scope.
ST131 plasmids possess a transef region that allows one bacterium to pass a genetic material (the plasmid) to another through direct contact in the process known as the conjugation. Despite the seeming importance of the conjugation for a bacterial population, ST131 plasmids exsibit multiple variations in the transfer region. The effect of rearrangments on the conjugation rate is studied. Kira Kondratyeva

Anat Shnaiderman veterinarian

Antibiotic-resistance pathogens in the companion animals

In recent years, a rise in carriage of extended-spectrum-β-lactamases (ESBLs) in livestock and companion animals is documented, and forms a new field of study and opportunities to further investigate the dynamics of transfer and carriage of these antibiotic resistant genes. We study antibiotic resistant enteric bacteria, originated from companion animals, mainly horses and especially neonatal foals, dogs and cats.
Companion animals are likely to be a reservoir of antibiotic resistant genes, and a better understanding of the acquisition and duration of carriage of ESBL producers in these animals, might lead to new and improved approaches to monitor and control the spread of these pathogens. Dr. Anat ShnaidermanZiv Dor

Mice model

Competition test to define the dominance and the submissiveness of mice
Measured as the relative success of two food-restricted mice to gain access to a feeder

Gut microbiome influence on behavior

Recent studies have demonstrated that commensal, probiotic, and pathogenic bacteria in the gastrointestinal tract can activate central nervous signaling systems, possibly through neural, endocrine and immune pathways.
We study the connection between the gut microbiome and behavior using a mouse model of social interaction. We developed two mouse strains from a parent strain which show marked differences in metabolism, gut microbiome, gene expression, social behavior, anxiety- and depressive-like behaviors, and stress vulnerability. We aim to reveal useful insights into bacterial-eukaryotic interactions and the gut-brain axis cross talk.Oryan AgranyoniSapir Meninger