Research Activity

  • Birk R, Bravdo B, Shosseyov O. Detoxification of cassava by Aspergillus niger B-1. Applied Microbiology and Biotechnology (1996) 45:411-414.
  • Birk R, Ikan A, Bravdo B, Braun S, Shoseyov O. Synthesis of isopropyl-1-thio-b-D-Glucopyranoside (IPTGlc), an inducer of Aspergillus niger B1 b-glucosidase production. Applied Biochemistry and Biotechnology (1997) 66:25-30.
  • Birk R.Z, Karen S. Regan and Brannon PM. Circulating leptin levels in newborn rats: A significant post- natal developmental effect, independent of dietary polyunsaturated fat levels. Life Sciences, (2003) 73:2761-2767.
  • Birk R.Z, Brannon PM. Regulation of pancreatic lipase by dietary medium chain triglycerides in the weanling rat. Pediatric Research (2004) 55(6): 921-926.
  • Birk R.Z, Regan K, Brannon PM. Pancreatic Lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the post-natal development of rats. Pediatric Research (2004) 56(2): 256-262.
  • Birk R.Z, Regan K, Brannon PM. Lactation decreases pancreatic lipase mRNA level in the rat.
    British Journal of Nutrition (2005) 94(6):885-889.
  • Birk R.Z, Borenstein E, Wiznitzer A. Correlation between placental Angiopoietin 1 and angiopoietin 2 expression and twin weight.
    The Journal of Maternal-Fetal and Neonatal Medicine. (2005) 17(5): 337–342.
  • Jim Kaput, Jose M. Ordovas, Lynn Ferguson, Ben van Ommen, Raymond L.Rodriguez, Lindsay Allen, Bruce N. Ames, Kevin Dawson, Bruce German, Ronald
    Krauss, Wasyl Malyj, Michael C. Archer, Stephen Barnes, Amelia Bartholomew,Ruth Birk, et al.
    The Case for Strategic International Alliances to Harness Nutritional Genomics for Public and Personal Health.
    British Journal of Nutrition (2005) 94:623-632.
  • Birk R.Z. Forti E., Margalit E., Dekel M, Abramovich-Guttliv L., Vago R. Conversion of adipogenic to osteogenic phenotype using crystalline porous
    biomatrices of marine origin.
    Tissue Engineering (2006) 12(1):21-31.
  • Birk R.Z. and Rubinstein M. INF- γ induced apoptosis of adipose tissue.
    Biochemical and Biophysical Research Communications (2006) 345(2): 669-674.
  • Landau Z., Alcaly M., Forti E., Birk R.Z.
    Palmitate-induced Lipoapoptotic effects on exocrine pancreas AR42J cells.
    Apoptosis (2006) 11 (5): 717-724.
  • Elinson N., Amichay D., Birk R.Z.
    Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat.
    British Journal Nutrition (2006) 96(4):691-6.
  • Birk R.Z. and Rubinstein M.
    Leptin restores plasma cholesterol, glucose and weight loss induced by IFN-γ treatment.
    Biochemical and Biophysical Research Communications (2007) 355(3):626-31.
  • Forti E., Aksanov O., Birk R.Z. Temporal Expression Pattern of Bardet Biedl Syndrome Genes in Adipogenesis
    The International Journal of Biochemistry & Cell Biology (2007) 39(5):1055-62.
  • Forti E. and Birk RZ. CLA down regulates expression of resistin and adiponectin in fully differentiated
    3T3-F442A.
    Genes & Nutrition (2007) 2:119-120.
  • Dagai L., Peri-Naor R. and Birk R.Z. Docosahexaenoic acid significantly stimulates immediate early response genes and
    neurite outgrowth.
    Neurochemical Research (2008) 34(5):867-75.
  • Eynon N, Ruiz JR, Oliveira J, Duarte JA, Birk R, Lucia A.  Genes and elite athletes: A roadmap for future research-Topical Review.
    Journal of  Physiology (2011) 589(Pt 13):3063-3070 .
    Note: Eynon N is a post-doc in my lab, fully guided by me.
  • Eynon N, Moran M, Birk R, Lucia A.  The champions’ mitochondria: Is it genetically determined? A review on mitochondrial DNA and elite athletic performance.
    Physiological Genomics. (2011) 43(13):789-798.
  • Eynon N, Birk R, Meckel Y, Lucia A, Nemet D, Eliakim A.
    Physiological variables and mitochondrial-related genotypes of an elite athlete who excels in both short and long-distance running.
    Mitochondrion. (2011) 11(5):774-777.
  • Eynon N and Birk R.  Using genetic tests for talent identification in sports: too soon to be true.
    Journal of Pediatric Endocrinology (2011) 24(7-8):607-608.
  • Eynon N, Ruiz JR, Yvert T, Santiago C, Gómez-Gallego F, Lucia A, Birk R
    The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player’s Status.
    Int J Sports Med. (2012) 33(7):521-524.
  • Eynon N, Ruiz JR, Bishop D, Santiago C, Gómez-Gallego F, Lucia A, Birk R. The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete’s performance status.
    Journal of Science and Medicine in Sport. (2013) 16(2):135-9.
  • Eynon N, Ruiz JR, Pushkarev VP, Ci?szczyk P, Maciejewska-Karlowska A, Sawczuk M, Dyatlov DA, Lekontsev EV,  Kulikov LM, Birk R, Femia P, Bishop D, Lucia A. The ACTN3 R577X polymorphism across three groups of elite male European athletes.
    PloS One (2012) 7(8):e43132.
  • Birk RZ,  GIANT Consortium, Ermakov S, Livshits G.  Common fSNP variants of fourteen Bardet-Biedl syndrome genes and adult body mass.
    OBESITY 2013 8,1684-9.
  • Raz M, Sharon Y, Yerushalmi B, Birk RZ.
    Frequency of Lct -13910C/T And Lct – 22018 G/A Single Nucleotide Polymorphisms Associated with Adult-Type Hypolactasia /Lactase Persistence Among Israelis
    Different Ethnic Groups.
  • Gene (2013) 519(1):67-70.
  • Efrat M, Tepper S, Birk RZ.  From fat cell biology to public health preventive strategies – pinpointing the critical period for obesity prevention.
    Journal of Pediatric Endocrinology and Metabolism (2013) 26(3-4):197-209.
  • Eynon N, Nasibulina ES, Banting L, Cieszczyk P, Maciejewska-Karlowska A, Sawczuk M, Bondareva EA, Raz M, Sharon Y, Williams AG, Ahmetov II, Lucia A,  Birk R. The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes. PloS One (2013) 8(4):e60570.
  • Birk RZ, Rubio-Aliaga I, Boekschoten MV, Müller M, Daniel H.
    Differential regulation of pancreatic digestive enzymes during chronic high fat diet-induced-obesity in C57BL/6J mice.
    British Journal of Nutrition 2014;112(2):154-61
  • Aksanov O, Green P, Birk RZ. BBS4 and adipocyte function. Cellular and Molecular Life Sciences 2014;71(17):3381-92.
  • Bachar A, Hermoni D, Livshits G,  Birk R, Late successful weight reduction and maintenance among overweight and obese adults – a two year retrospective study.
    Diabetes Research and Clinical Practice 2014;106(3):511-21
  • Heifetz EM and Birk RZ. MTHFR C677T polymorphism effect normotensive diastolic blood pressure, independently of blood lipids, in Israeli women. American Journal of Hypertension 2014:28(3):387-92.
  • Banting L, Pushkarev VP, Cieszczyk P, Zarebska A, Maciejewska-Karlowska A, Sawczuk M, Leonska-Duniec A, Dyatlov DA, Orekhov EF, Degtyarev AV, Pushkareva YE, Yan X, Birk R* and Eynon N*. Elite athletes’ genetic predisposition for altered risk of complex metabolic traits. BMC Genomics 2015  23;16(1):25.
    * Equal contribution
  • Danino H, Ben-Dror K, Birk R. Exocrine pancreas ER stress differentially induced by different fatty acids.
    Experimental Cell Research 2015; 339(2):397-406.
  • Salam H, Rosenfeld T,  Altarescu  G,  Grisaru-Granovsky S,  Tevet  A,  Birk R.
    Maternal and fetal leptin polymorphisms significantly associated with pregnancy duration. Gene 2016;591(1):209-213.
  • Liron Danielpor, Yang-Sung Sohn, Ola Karmi, Chen Fogel, Adar Zinger, Tal Israeli, Yael Riahi, Ruth Birk, David H Zangen, Ron Mittler, Ioav Z Cabantchik, Erol Cerasi, Rachel Nechushtai, Gil Leibowitz. GLP-1 receptor agonist corrects mitochondrial iron overload and improves pancreatic -cell function in type 2 Wolfram syndrome. The Journal of Clinical Endocrinology & Metabolism 2016;10:3592-3599.
  • Peri- Naor R, Danino H, Fogel C, Ben-Harosh Y,  Birk R.  PPARγ Regulates exocrine pancreas lipase  (Accepted and provisional patent submitted). BBA -Molecular and Cell Biology of Lipids 2016; 12:1921-1928.
  • Nahum N. Forti E, Aksanov O  and Birk R. Insulin regulates Bbs4 during adipogenesis.
    IUBMB Life 2017.
  • Rosenfeld T, Salem H, Altarescu G, Grisaru-Granovsky S, Tevet A, Birk R.
    Maternal and fetal vitamin D receptor polymorphisms significantly associated with pregnancy duration.
    Archives of Gynecology and Obstetrics 2017 ;296(2):215-222.
  • Perez Y, Wormser O, Sadka Y, Birk R, Narkis G, Birk OS.
    A rare variant in PGAP2 causes autosomal recessive hyperphosphatasia with mental retardation syndrome, with a mild phenotype in heterozygous carriers.
    Biomed Res Intern 2017; 3470234
  • Ben-Harosh Y, Anosov M, Salem H, Yatchenko Y, Birk R.
    Pancreatic stellate cell activation is regulated by fatty acids and ER stress.
    Exp Cell Res 2017;359(1):76-85.
  • Yogev Y, Perez Y, Noyman I, Madegem AA, Flusser H, Shorer Z, Cohen E, Kachko L, Michaelovsky A, Birk R, Koifman A, Drabkin M, Wormser O, Halperin D, Kadir R, Birk OS. Progressive hereditary spastic paraplegia caused by a homozygous KY mutation.
    Eur J Hum Genet. 2017; 25(8):966-972.
  • Salem H, Rosenfeld T, Yekaterina Yatchenko, Mariana Anoosov, Altarescu G, Grisaru-Granovsky S, Birk R.
    Maternal and fetal Irisin polymorphisms significantly associated with pregnancy duration. Gene 2018; 649:58-62.
  • Bachar A, Livshits G, Birk R.
    Predictors of weight reduction and maintenance in large cohort of overweight and obese adults in a community setting.
    Dietetics and Nutrition 2018; 75(4):390-396.
  • Efrat M, Stein A, Pinkas H, Unger U, Birk R.
    Dietary indexes are positively associated with semen quality.
    Fertility and Sterility 2018; 109(5):809-816.
  • Birk R and Heifez E. Variations in Biochemical Values for Common Laboratory Tests: A Comparison Among Multi-ethnic Women Cohort. Irish Journal of Medical Science 2019;188(1):249-258.
  • Efrat M, Stein A, Pinkas H, Unger U, Birk R.
    Paraoxonase 1 (PON1) attenuates sperm hyperactivity and spontaneous acrosome reaction. Andrology 2019;7(1):24-30.
  • Wormser O, Gradstein L, Yogev Y, Perez Y, Kadir R, Goliand I, Sadka Y, El Riati S, Flusser H, Nachmias D, Birk R, Iraqi M, Kadar E, Gat R, Drabkin M, Halperin D, Horev A, Sivan S, Abdu U, Elia N, Birk OS. SCAPER localizes to primary cilia and its mutation affects cilia length, causing Bardet-Biedl syndrome. Eur J Hum Genet. 2019;27(6):928-940.
  • Kaufman-Shriqui V, Salem H, Birk R, Boaz M. Nutrition Knowledge Translation Performance in Health Professionals: Findings from the 2017 Unified Forces Preventive Nutrition Conference (UFPN). Nutrients. 2019 ;13;11(2) .
  • Yatchenko Y, Horwitz A, Birk R. Endocrine and exocrine pancreas pathologies crosstalk: Insulin regulates the unfolded protein response in pancreatic exocrine acinar cells. Exp Cell Res. 2019 ;15;375(2):28-35.
  • Halperin D, Kadir R, Perez Y, Drabkin M, Yogev Y, Wormser O, Berman EM, Eremenko E, Rotblat B, Shorer Z, Gradstein L, Shelef I, Birk R, Abdu U, Flusser H, Birk OS. SEC31A mutation affects ER homeostasis, causing a neurological syndrome. J Med Genet. 2019;56(3):139-148.
  • Anosov M, Birk R. Bardet-Biedl syndrome obesity: BBS4 regulates cellular ER stress in early adipogenesis. Mol Genet Metab. 2019; 15: S1096-7192(19)30042-3.
  • Ben-Dror K, Birk R. Oleic acid ameliorates palmitic acid-induced ER stress and inflammation markers in naive and cerulein-treated exocrine pancreas cells. Biosci Rep. 2019 14;39(5).
  • Kaufman-Shriqui V, Salem H, Boaz M, Birk R, Knowledge and Attitudes Towards Nutrigenetics: Findings from the 2019 Unified Forces Preventive Nutrition Conference (UFPN). Nutrients. 2020. 27;12(2):335.

Selected Research Grants, active 2010 and on (competitive, peer-reviewed; PI or Co-PI)

 

Cystic Fibrosis Foundation (U.S.): 180,000$

Israeli Ministry of Health: 180,000 NIS

ISF – Legacy Heritage Foundation (Morasha) biomedical research grant: 240,000$

Israeli Ministry of Health: 150,000 NIS

Israeli Ministry of Health: 100,000 NIS

Selected publications

  • Birk R, Bravdo B, Shosseyov O. Detoxification of cassava by Aspergillus niger B-1. Applied Microbiology and Biotechnology (1996) 45:411-414.
  • Birk R, Ikan A, Bravdo B, Braun S, Shoseyov O. Synthesis of isopropyl-1-thio-b-D-Glucopyranoside (IPTGlc), an inducer of Aspergillus niger B1 b-glucosidase production. Applied Biochemistry and Biotechnology (1997) 66:25-30.
  • Birk R.Z, Karen S. Regan and Brannon PM. Circulating leptin levels in newborn rats: A significant post- natal developmental effect, independent of dietary polyunsaturated fat levels. Life Sciences, (2003) 73:2761-2767.
  • Birk R.Z, Brannon PM. Regulation of pancreatic lipase by dietary medium chain triglycerides in the weanling rat. Pediatric Research (2004) 55(6): 921-926.
  • Birk R.Z, Regan K, Brannon PM. Pancreatic Lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the post-natal development of rats. Pediatric Research (2004) 56(2): 256-262.
  • Birk R.Z, Regan K, Brannon PM. Lactation decreases pancreatic lipase mRNA level in the rat.
    British Journal of Nutrition (2005) 94(6):885-889.
  • Birk R.Z, Borenstein E, Wiznitzer A. Correlation between placental Angiopoietin 1 and angiopoietin 2 expression and twin weight.
    The Journal of Maternal-Fetal and Neonatal Medicine. (2005) 17(5): 337–342.
  • Jim Kaput, Jose M. Ordovas, Lynn Ferguson, Ben van Ommen, Raymond L.Rodriguez, Lindsay Allen, Bruce N. Ames, Kevin Dawson, Bruce German, Ronald
    Krauss, Wasyl Malyj, Michael C. Archer, Stephen Barnes, Amelia Bartholomew,Ruth Birk, et al.
    The Case for Strategic International Alliances to Harness Nutritional Genomics for Public and Personal Health.
    British Journal of Nutrition (2005) 94:623-632.
  • Birk R.Z. Forti E., Margalit E., Dekel M, Abramovich-Guttliv L., Vago R. Conversion of adipogenic to osteogenic phenotype using crystalline porous
    biomatrices of marine origin.
    Tissue Engineering (2006) 12(1):21-31.
  • Birk R.Z. and Rubinstein M. INF- γ induced apoptosis of adipose tissue.
    Biochemical and Biophysical Research Communications (2006) 345(2): 669-674.
  • Landau Z., Alcaly M., Forti E., Birk R.Z.
    Palmitate-induced Lipoapoptotic effects on exocrine pancreas AR42J cells.
    Apoptosis (2006) 11 (5): 717-724.
  • Elinson N., Amichay D., Birk R.Z.
    Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat.
    British Journal Nutrition (2006) 96(4):691-6.
  • Birk R.Z. and Rubinstein M.
    Leptin restores plasma cholesterol, glucose and weight loss induced by IFN-γ treatment.
    Biochemical and Biophysical Research Communications (2007) 355(3):626-31.
  • Forti E., Aksanov O., Birk R.Z. Temporal Expression Pattern of Bardet Biedl Syndrome Genes in Adipogenesis
    The International Journal of Biochemistry & Cell Biology (2007) 39(5):1055-62.
  • Forti E. and Birk RZ. CLA down regulates expression of resistin and adiponectin in fully differentiated
    3T3-F442A.
    Genes & Nutrition (2007) 2:119-120.
  • Dagai L., Peri-Naor R. and Birk R.Z. Docosahexaenoic acid significantly stimulates immediate early response genes and
    neurite outgrowth.
    Neurochemical Research (2008) 34(5):867-75.
  • Eynon N, Ruiz JR, Oliveira J, Duarte JA, Birk R, Lucia A.  Genes and elite athletes: A roadmap for future research-Topical Review.
    Journal of  Physiology (2011) 589(Pt 13):3063-3070 .
    Note: Eynon N is a post-doc in my lab, fully guided by me.
  • Eynon N, Moran M, Birk R, Lucia A.  The champions’ mitochondria: Is it genetically determined? A review on mitochondrial DNA and elite athletic performance.
    Physiological Genomics. (2011) 43(13):789-798.
  • Eynon N, Birk R, Meckel Y, Lucia A, Nemet D, Eliakim A.
    Physiological variables and mitochondrial-related genotypes of an elite athlete who excels in both short and long-distance running.
    Mitochondrion. (2011) 11(5):774-777.
  • Eynon N and Birk R.  Using genetic tests for talent identification in sports: too soon to be true.
    Journal of Pediatric Endocrinology (2011) 24(7-8):607-608.
  • Eynon N, Ruiz JR, Yvert T, Santiago C, Gómez-Gallego F, Lucia A, Birk R
    The C Allele in NOS3 -786 T/C Polymorphism is Associated with Elite Soccer Player’s Status.
    Int J Sports Med. (2012) 33(7):521-524.
  • Eynon N, Ruiz JR, Bishop D, Santiago C, Gómez-Gallego F, Lucia A, Birk R. The rs12594956 polymorphism in the NRF-2 gene is associated with top-level Spanish athlete’s performance status.
    Journal of Science and Medicine in Sport. (2013) 16(2):135-9.
  • Eynon N, Ruiz JR, Pushkarev VP, Ci?szczyk P, Maciejewska-Karlowska A, Sawczuk M, Dyatlov DA, Lekontsev EV,  Kulikov LM, Birk R, Femia P, Bishop D, Lucia A. The ACTN3 R577X polymorphism across three groups of elite male European athletes.
    PloS One (2012) 7(8):e43132.
  • Birk RZ,  GIANT Consortium, Ermakov S, Livshits G.  Common fSNP variants of fourteen Bardet-Biedl syndrome genes and adult body mass.
    OBESITY 2013 8,1684-9.
  • Raz M, Sharon Y, Yerushalmi B, Birk RZ.
    Frequency of Lct -13910C/T And Lct – 22018 G/A Single Nucleotide Polymorphisms Associated with Adult-Type Hypolactasia /Lactase Persistence Among Israelis
    Different Ethnic Groups.
  • Gene (2013) 519(1):67-70.
  • Efrat M, Tepper S, Birk RZ.  From fat cell biology to public health preventive strategies – pinpointing the critical period for obesity prevention.
    Journal of Pediatric Endocrinology and Metabolism (2013) 26(3-4):197-209.
  • Eynon N, Nasibulina ES, Banting L, Cieszczyk P, Maciejewska-Karlowska A, Sawczuk M, Bondareva EA, Raz M, Sharon Y, Williams AG, Ahmetov II, Lucia A,  Birk R. The FTO A/T Polymorphism and Elite Athletic Performance: A Study Involving Three Groups of European Athletes. PloS One (2013) 8(4):e60570.
  • Birk RZ, Rubio-Aliaga I, Boekschoten MV, Müller M, Daniel H.
    Differential regulation of pancreatic digestive enzymes during chronic high fat diet-induced-obesity in C57BL/6J mice.
    British Journal of Nutrition 2014;112(2):154-61
  • Aksanov O, Green P, Birk RZ. BBS4 and adipocyte function. Cellular and Molecular Life Sciences 2014;71(17):3381-92.
  • Bachar A, Hermoni D, Livshits G,  Birk R, Late successful weight reduction and maintenance among overweight and obese adults – a two year retrospective study.
    Diabetes Research and Clinical Practice 2014;106(3):511-21
  • Heifetz EM and Birk RZ. MTHFR C677T polymorphism effect normotensive diastolic blood pressure, independently of blood lipids, in Israeli women. American Journal of Hypertension 2014:28(3):387-92.
  • Banting L, Pushkarev VP, Cieszczyk P, Zarebska A, Maciejewska-Karlowska A, Sawczuk M, Leonska-Duniec A, Dyatlov DA, Orekhov EF, Degtyarev AV, Pushkareva YE, Yan X, Birk R* and Eynon N*. Elite athletes’ genetic predisposition for altered risk of complex metabolic traits. BMC Genomics 2015  23;16(1):25.
    * Equal contribution
  • Danino H, Ben-Dror K, Birk R. Exocrine pancreas ER stress differentially induced by different fatty acids.
    Experimental Cell Research 2015; 339(2):397-406.
  • Salam H, Rosenfeld T,  Altarescu  G,  Grisaru-Granovsky S,  Tevet  A,  Birk R.
    Maternal and fetal leptin polymorphisms significantly associated with pregnancy duration. Gene 2016;591(1):209-213.
  • Liron Danielpor, Yang-Sung Sohn, Ola Karmi, Chen Fogel, Adar Zinger, Tal Israeli, Yael Riahi, Ruth Birk, David H Zangen, Ron Mittler, Ioav Z Cabantchik, Erol Cerasi, Rachel Nechushtai, Gil Leibowitz. GLP-1 receptor agonist corrects mitochondrial iron overload and improves pancreatic -cell function in type 2 Wolfram syndrome. The Journal of Clinical Endocrinology & Metabolism 2016;10:3592-3599.
  • Peri- Naor R, Danino H, Fogel C, Ben-Harosh Y,  Birk R.  PPARγ Regulates exocrine pancreas lipase  (Accepted and provisional patent submitted). BBA -Molecular and Cell Biology of Lipids 2016; 12:1921-1928.
  • Nahum N. Forti E, Aksanov O  and Birk R. Insulin regulates Bbs4 during adipogenesis.
    IUBMB Life 2017.